The Binding of Isaac is a game for Microsoft Windows, Mac OS, and Linux. It is a top-down shooter rougelike game. Basically the story is you're just a kid named Isaac, and you live a happy life with your mother, who watches religious television shows all day. One day God speaks to her and tells her that you, Isaac, are filled with sin and must be killed. You see your mother walk towards the door, knife in hand, ready to do the bidding of her Lord. Isaac sees this and runs into a trapdoor that is in his room, leading to the basement. This is where the game begins. You have to explore the depths of your basement, fighting various monsters, while trying to escape your mother. Throughout the game you find powerups that enhance your life capacity, your tear style (what you shoot), how fast you shoot tears, your strength, luck, speed, etc. This game is also perma-death, meaning that once you die you're done. To play again you have to start all over. The game has an amazing soundtrack as well. As you play you also have the ability to unlock other characters, which change your starting abilities. Isaac, Eve, Cain, Judas, Samson, Blue Baby, and Maggy are all playable characters. If you haven't noticed already (though I don't see how you couldn't) this game is very religiously influenced. There is roughly 50 bosses in the game. This link will take you to a list of the bosses. This link takes you to the wiki about the game.
Here is an example of some boss monsters:
Monstro
Loki
The Fallen
It Lives
Satan
Monstro II
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